Messina to Syracuse trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Messina Centrale and arrive at Siracusa every about 4 hours on average. If travelling with Trenitalia, you need to know the Messina to Syracuse train schedule: the first train leaves at 17:20, while the last ride is at 17:20. Trenitalia offers 1 direct trains between these two cities. Thanks to Trenitalia, offers, you can save on your trip from Messina to Syracuse and find low cost tickets starting from 10 €! If you need to travel this week, prices range from 20.50 € to 20.50€.