Messina to Trieste trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Messina Centrale and arrive at Trieste Centrale every about 2 hours on average. If travelling with Trenitalia, you need to know the Messina to Trieste train schedule: the first train leaves at 00:35, while the last ride is at 22:10. A Messina to Trieste train cost about 112.5 €. But how long is the train ride from Messina to Trieste? Your journey takes about 17 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Messina to Trieste and find low cost tickets starting from 110 €!