Messina to Varese trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Messina Centrale and arrive at Varese every about 3 hours on average. If travelling with Trenitalia, you need to know the Messina to Varese train schedule: the first train leaves at 16:40, while the last ride is at 22:10. A Messina to Varese train cost about 107.5 €. But how long is the train ride from Messina to Varese? Your journey takes about 17 hours on average.