Mestre to Agrigento trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Venezia Mestre and arrive at Agrigento Centrale every about 3 hours on average. If travelling with Trenitalia, you need to know the Mestre to Agrigento train schedule: the first train leaves at 00:21, while the last ride is at 18:37. A Mestre to Agrigento train cost about 113.75 €. But how long is the train ride from Mestre to Agrigento? Your journey takes about 14 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Mestre to Agrigento and find low cost tickets starting from 71 €!