Mestre to Agrigento trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Venezia Mestre and arrive at Agrigento Centrale every about 3 hours on average. If travelling with Trenitalia, you need to know the Mestre to Agrigento train schedule: the first train leaves at 00:21, while the last ride is at 18:37. A Mestre to Agrigento train cost about 113.75 €. But how long is the train ride from Mestre to Agrigento? Your journey takes about 14 hours on average.