Mestre to Ancona trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Venezia Mestre and arrive at Ancona every 30 minutes on average. If travelling with Trenitalia, you need to know the Mestre to Ancona train schedule: the first train leaves at 07:09, while the last ride is at 19:54. A Mestre to Ancona train cost about 23.65 €. But how long is the train ride from Mestre to Ancona? Your journey takes about 5 hours on average. Trenitalia offers 2 direct trains between these two cities. Thanks to Trenitalia, offers, you can save on your trip from Mestre to Ancona and find low cost tickets starting from 29 €!