Mestre to Asti trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Milano Centrale and arrive at Asti every 30 minutes on average. If travelling with Trenitalia, you need to know the Mestre to Asti train schedule: the first train leaves at 05:18, while the last ride is at 20:10. A Mestre to Asti train cost about 11.40 €. But how long is the train ride from Mestre to Asti? Your journey takes about 3 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Mestre to Asti and find low cost tickets starting from 11 €! When booking your train ticket a few weeks in advance though, you can find low cost trains from Mestre to Asti with fares starting from 11.40€, saving up to 25%.