Mestre to Lecce trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Venezia S. Lucia and arrive at Lecce every about 1 hour on average. If travelling with Trenitalia, you need to know the Mestre to Lecce train schedule: the first train leaves at 00:08, while the last ride is at 19:42. A Mestre to Lecce train cost about 71.6 €. But how long is the train ride from Mestre to Lecce? Your journey takes about 11 hours on average. Trenitalia offers 2 direct trains between these two cities. Thanks to Trenitalia, offers, you can save on your trip from Mestre to Lecce and find low cost tickets starting from 39 €!