Mestre to Marsala trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Venezia S. Lucia and arrive at Spagnuola every about 12 hours on average. If travelling with Trenitalia, you need to know the Mestre to Marsala train schedule: the first train leaves at 18:25, while the last ride is at 18:25. A Mestre to Marsala train cost about 129.9 €. But how long is the train ride from Mestre to Marsala? Your journey takes about 2 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Mestre to Marsala and find low cost tickets starting from 131 €!