Mestre to Marsala trains might be a good value for money solution; travelling in Italy by train is often rather cheap and faster than taking a bus indeed. You can count on 1 daily rides to get from Mestre to Marsala. Trains leave from Venezia S. Lucia and arrive at Spagnuola every about 12 hours on average. The trip by train from Mestre to Marsala last on average 01:44 travelling with high-speed trains (Frecciarossa or Italotreno) If travelling with Trenitalia, you need to know the Mestre to Marsala train schedule: the first train leaves at 18:25, while the last ride is at 18:25. A Mestre to Marsala train cost about 129.9 €. But how long is the train ride from Mestre to Marsala? Your journey takes about 2 hours on average. Thanks to Trenitalia offers, you can save on your trip from Mestre to Marsala and find prices starting from 131 €!