Mestre to Sciacca trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Venezia S. Lucia and arrive at Castelvetrano every about 3 hours on average. If travelling with Trenitalia, you need to know the Mestre to Sciacca train schedule: the first train leaves at 00:08, while the last ride is at 00:08. A Mestre to Sciacca train cost about 153.65 €. But how long is the train ride from Mestre to Sciacca? Your journey takes about 22 hours on average.