Milan to Caltanissetta trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Milano Centrale and arrive at Caltanissetta Centrale every about 4 hours on average. If travelling with Trenitalia, you need to know the Milan to Caltanissetta train schedule: the first train leaves at 19:00, while the last ride is at 22:15. A Milan to Caltanissetta train cost about 87.0 €. But how long is the train ride from Milan to Caltanissetta? Your journey takes about 20 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Milan to Caltanissetta and find low cost tickets starting from 124 €!