Milan to Messina trains might be a good value for money solution; travelling in Italy by train is often rather cheap and faster than taking a bus indeed. You can count on 4 daily rides to get from Milan to Messina. Trains leave from Milano Centrale and arrive at Messina Centrale every about 3 hours on average. The trip by train from Milan to Messina last on average 11:15 travelling with high-speed trains (Frecciarossa or Italotreno) If travelling with Trenitalia, you need to know the Milan to Messina train schedule: the first train leaves at 08:15, while the last ride is at 22:15. A Milan to Messina train cost about 108.3 €. But how long is the train ride from Milan to Messina? Your journey takes about 14 hours on average. Trenitalia offers 1 direct trains between these two cities. Thanks to Trenitalia offers, you can save on your trip from Milan to Messina and find prices starting from 39 €!