To get from Milan to Messina by train you can catch one of the 4 trains that everyday travel between these two cities. The first train to Messina leaves from Milan at 08:15 and the last train departs at 22:15. The trip by train from Milan to Messina last on average 11:15 travelling with high-speed trains (Frecciarossa or Italotreno) If you choose a local train the trip lasts on average 16:40 hours. For your trip from Milan to Messina by train you can choose to leave from one of Milan main stations: Milano Centrale Prices for next month range from € 104 to € 104. The most economic train is Frecciarossa () that departs at 08:15 and arrives in Messina at 19:30 at € 104. On Wanderio you can compare all schedules, fares and railway companies to Messina and book the best itinerary starting from Milan.