Milan to Niscemi trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Milano Centrale and arrive at Niscemi every about 3 hours on average. If travelling with Trenitalia, you need to know the Milan to Niscemi train schedule: the first train leaves at 19:00, while the last ride is at 22:15. A Milan to Niscemi train cost about 119.3 €. But how long is the train ride from Milan to Niscemi? Your journey takes about 12 hours on average.