Milan to Syracuse trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Milano Porta Venezia and arrive at Siracusa every about 3 hours on average. If travelling with Trenitalia, you need to know the Milan to Syracuse train schedule: the first train leaves at 07:54, while the last ride is at 22:09. A Milan to Syracuse train cost about 73.0 €. But how long is the train ride from Milan to Syracuse? Your journey takes about 17 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Milan to Syracuse and find low cost tickets starting from 37 €!