Milan to Syracuse trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Milano Porta Venezia and arrive at Siracusa every about 3 hours on average. If travelling with Trenitalia, you need to know the Milan to Syracuse train schedule: the first train leaves at 07:54, while the last ride is at 22:09. A Milan to Syracuse train cost about 73.0 €. But how long is the train ride from Milan to Syracuse? Your journey takes about 17 hours on average.