Molfetta to Syracuse trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Molfetta and arrive at Siracusa every about 3 hours on average. If travelling with Trenitalia, you need to know the Molfetta to Syracuse train schedule: the first train leaves at 06:31, while the last ride is at 22:31. A Molfetta to Syracuse train cost about 71.2 €. But how long is the train ride from Molfetta to Syracuse? Your journey takes about 17 hours on average.