Monopoli to Alessandria trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Monopoli and arrive at Alessandria every about 1 hour on average. If travelling with Trenitalia, you need to know the Monopoli to Alessandria train schedule: the first train leaves at 04:41, while the last ride is at 23:40. A Monopoli to Alessandria train cost about 67.0 €. But how long is the train ride from Monopoli to Alessandria? Your journey takes about 12 hours on average. Trenitalia offers 1 direct trains between these two cities.