Monopoli to Comiso trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Monopoli and arrive at Comiso every about 12 hours on average. If travelling with Trenitalia, you need to know the Monopoli to Comiso train schedule: the first train leaves at 21:54, while the last ride is at 21:54. A Monopoli to Comiso train cost about 65.35 €. But how long is the train ride from Monopoli to Comiso? Your journey takes about 1 hour on average.