Monopoli to Palermo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Monopoli and arrive at Palermo Centrale every about 6 hours on average. If travelling with Trenitalia, you need to know the Monopoli to Palermo train schedule: the first train leaves at 04:41, while the last ride is at 23:40. A Monopoli to Palermo train cost about 56.0 €. But how long is the train ride from Monopoli to Palermo? Your journey takes about 19 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Monopoli to Palermo and find low cost tickets starting from 46 €!