Monopoli to Palermo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Monopoli and arrive at Palermo Centrale every about 6 hours on average. If travelling with Trenitalia, you need to know the Monopoli to Palermo train schedule: the first train leaves at 04:41, while the last ride is at 23:40. A Monopoli to Palermo train cost about 56.0 €. But how long is the train ride from Monopoli to Palermo? Your journey takes about 19 hours on average.