Monopoli to Syracuse trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Monopoli and arrive at Siracusa every about 12 hours on average. If travelling with Trenitalia, you need to know the Monopoli to Syracuse train schedule: the first train leaves at 06:38, while the last ride is at 06:38. A Monopoli to Syracuse train cost about 64.2 €. But how long is the train ride from Monopoli to Syracuse? Your journey takes about 16 hours on average.