Niscemi to Alessandria trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Niscemi and arrive at Alessandria every about 6 hours on average. If travelling with Trenitalia, you need to know the Niscemi to Alessandria train schedule: the first train leaves at 06:22, while the last ride is at 13:15. A Niscemi to Alessandria train cost about 120.15 €. But how long is the train ride from Niscemi to Alessandria? Your journey takes about 2 hours on average.