Niscemi to Messina trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Niscemi and arrive at Messina Centrale every about 4 hours on average. If travelling with Trenitalia, you need to know the Niscemi to Messina train schedule: the first train leaves at 06:22, while the last ride is at 18:08. A Niscemi to Messina train cost about 11.0 €. But how long is the train ride from Niscemi to Messina? Your journey takes about 5 hours on average.