Novi Ligure to Comiso trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Novi Ligure and arrive at Comiso every about 6 hours on average. If travelling with Trenitalia, you need to know the Novi Ligure to Comiso train schedule: the first train leaves at 15:14, while the last ride is at 20:44. A Novi Ligure to Comiso train cost about 128.0 €. But how long is the train ride from Novi Ligure to Comiso? Your journey takes about 23 hours on average.