Osimo to Alessandria trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Ancona, Osimo-Castelfidardo and arrive at Milano Centrale, Firenze S. M. Novella, Alessandria, Milano Rogoredo every 15 minutes on average. If travelling with Trenitalia, you need to know the Osimo to Alessandria train schedule: the first train leaves at 06:10, while the last ride is at 22:24. A Osimo to Alessandria train cost about 19.90 €. But how long is the train ride from Osimo to Alessandria? Your journey takes about 5 hours on average. Trenitalia offers 10 direct trains between these two cities. Booking your train ticket a few weeks in advance though, you can find low cost trains from Osimo to Alessandria with fares starting from 19.90€, saving 36% on average.