Osimo to Comiso trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Osimo-Castelfidardo and arrive at Comiso every about 4 hours on average. If travelling with Trenitalia, you need to know the Osimo to Comiso train schedule: the first train leaves at 14:49, while the last ride is at 15:48. A Osimo to Comiso train cost about 99.0 €. But how long is the train ride from Osimo to Comiso? Your journey takes about 22 hours on average.