Osimo to Mazara del Vallo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Osimo-Castelfidardo and arrive at Mazara del Vallo every about 6 hours on average. If travelling with Trenitalia, you need to know the Osimo to Mazara del Vallo train schedule: the first train leaves at 14:49, while the last ride is at 14:52. A Osimo to Mazara del Vallo train cost about 177.8 €. But how long is the train ride from Osimo to Mazara del Vallo? Your journey takes about 23 hours on average.