Osimo to Niscemi trains might be a good value for money solution; travelling in Italy by train is often rather cheap and faster than taking a bus indeed. You can count on 2 daily rides to get from Osimo to Niscemi. Trains leave from Osimo-Castelfidardo and arrive at Niscemi every about 6 hours on average. If travelling with Trenitalia, you need to know the Osimo to Niscemi train schedule: the first train leaves at 13:51, while the last ride is at 19:14. A Osimo to Niscemi train cost about 182.85 €. But how long is the train ride from Osimo to Niscemi? Your journey takes about 3 hours on average.