Osimo to Palermo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Osimo-Castelfidardo and arrive at Palermo Centrale every about 4 hours on average. If travelling with Trenitalia, you need to know the Osimo to Palermo train schedule: the first train leaves at 13:50, while the last ride is at 13:55. A Osimo to Palermo train cost about 133.15 €. But how long is the train ride from Osimo to Palermo? Your journey takes about 20 hours on average.