Padua to Niscemi trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Padova and arrive at Niscemi every about 4 hours on average. If travelling with Trenitalia, you need to know the Padua to Niscemi train schedule: the first train leaves at 00:45, while the last ride is at 00:45. A Padua to Niscemi train cost about 163.65 €. But how long is the train ride from Padua to Niscemi? Your journey takes about 20 hours on average.