Palermo to Alessandria trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Palermo Notarbartolo and arrive at Alessandria every about 2 hours on average. If travelling with Trenitalia, you need to know the Palermo to Alessandria train schedule: the first train leaves at 09:10, while the last ride is at 20:44. A Palermo to Alessandria train cost about 116.35 €. But how long is the train ride from Palermo to Alessandria? Your journey takes about 22 hours on average.