Palermo to Messina trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Palermo Notarbartolo and arrive at Messina Centrale every about 2 hours on average. If travelling with Trenitalia, you need to know the Palermo to Messina train schedule: the first train leaves at 07:44, while the last ride is at 19:44. A Palermo to Messina train cost about 11.8 €. But how long is the train ride from Palermo to Messina? Your journey takes about 4 hours on average.