Palermo to Trieste trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Palermo Centrale and arrive at Trieste Centrale every about 2 hours on average. If travelling with Trenitalia, you need to know the Palermo to Trieste train schedule: the first train leaves at 07:00, while the last ride is at 21:10. A Palermo to Trieste train cost about 68 €. But how long is the train ride from Palermo to Trieste? Your journey takes about 21 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Palermo to Trieste and find low cost tickets starting from 39 €!