Perugia to Messina trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Perugia and arrive at Messina Centrale every about 4 hours on average. If travelling with Trenitalia, you need to know the Perugia to Messina train schedule: the first train leaves at 08:02, while the last ride is at 17:56. A Perugia to Messina train cost about 71.60 €. But how long is the train ride from Perugia to Messina? Your journey takes about 11 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Perugia to Messina and find low cost tickets starting from 61 €! When booking your train ticket a few weeks in advance though, you can find low cost trains from Perugia to Messina with fares starting from 18.47€, saving up to 58%.