Perugia to Niscemi trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Perugia and arrive at Niscemi every about 12 hours on average. If travelling with Trenitalia, you need to know the Perugia to Niscemi train schedule: the first train leaves at 17:56, while the last ride is at 17:56. A Perugia to Niscemi train cost about 137.25 €. But how long is the train ride from Perugia to Niscemi? Your journey takes about 23 hours on average.