Pesaro to Messina trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Pesaro and arrive at Messina Centrale every about 2 hours on average. If travelling with Trenitalia, you need to know the Pesaro to Messina train schedule: the first train leaves at 07:17, while the last ride is at 17:55. A Pesaro to Messina train cost about 106.0 €. But how long is the train ride from Pesaro to Messina? Your journey takes about 12 hours on average.