Piacenza to Brindisi trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Piacenza and arrive at Brindisi every about 1 hour on average. If travelling with Trenitalia, you need to know the Piacenza to Brindisi train schedule: the first train leaves at 06:29, while the last ride is at 22:30. A Piacenza to Brindisi train cost about 69.50 €. But how long is the train ride from Piacenza to Brindisi? Your journey takes about 9 hours on average. Trenitalia offers 7 direct trains between these two cities. Thanks to Trenitalia, offers, you can save on your trip from Piacenza to Brindisi and find low cost tickets starting from 49 €!