Pisa to Alessandria trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Pisa Centrale and arrive at Alessandria every 60 minutes on average. If travelling with Trenitalia, you need to know the Pisa to Alessandria train schedule: the first train leaves at 08:25, while the last ride is at 16:29. A Pisa to Alessandria train cost about 26.3 €. But how long is the train ride from Pisa to Alessandria? Your journey takes about 3 hours on average. Trenitalia offers 1 direct trains between these two cities. Thanks to Trenitalia, offers, you can save on your trip from Pisa to Alessandria and find low cost tickets starting from 17 €!