Pisa to Caltanissetta trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Pisa Centrale and arrive at Caltanissetta Centrale every about 3 hours on average. If travelling with Trenitalia, you need to know the Pisa to Caltanissetta train schedule: the first train leaves at 00:01, while the last ride is at 19:13. A Pisa to Caltanissetta train cost about 112.2 €. But how long is the train ride from Pisa to Caltanissetta? Your journey takes about 18 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Pisa to Caltanissetta and find low cost tickets starting from 110 €!