Pisa to Castelvetrano trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Pisa Centrale and arrive at Castelvetrano every about 2 hours on average. If travelling with Trenitalia, you need to know the Pisa to Castelvetrano train schedule: the first train leaves at 07:32, while the last ride is at 19:45. A Pisa to Castelvetrano train cost about 108.4 €. But how long is the train ride from Pisa to Castelvetrano? Your journey takes about 15 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Pisa to Castelvetrano and find low cost tickets starting from 88 €!