Pisa to Castelvetrano trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Pisa Centrale and arrive at Castelvetrano every about 2 hours on average. If travelling with Trenitalia, you need to know the Pisa to Castelvetrano train schedule: the first train leaves at 07:32, while the last ride is at 19:45. A Pisa to Castelvetrano train cost about 108.4 €. But how long is the train ride from Pisa to Castelvetrano? Your journey takes about 15 hours on average.