Pisa to Mazara del Vallo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Pisa Centrale and arrive at Mazara del Vallo every about 3 hours on average. If travelling with Trenitalia, you need to know the Pisa to Mazara del Vallo train schedule: the first train leaves at 00:01, while the last ride is at 19:13. A Pisa to Mazara del Vallo train cost about 114.9 €. But how long is the train ride from Pisa to Mazara del Vallo? Your journey takes about 21 hours on average.