Pisa to Mazara del Vallo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Pisa Centrale and arrive at Mazara del Vallo every about 3 hours on average. If travelling with Trenitalia, you need to know the Pisa to Mazara del Vallo train schedule: the first train leaves at 00:01, while the last ride is at 19:13. A Pisa to Mazara del Vallo train cost about 114.9 €. But how long is the train ride from Pisa to Mazara del Vallo? Your journey takes about 21 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Pisa to Mazara del Vallo and find low cost tickets starting from 49 €!