Pisa to Milazzo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Pisa Centrale and arrive at Milazzo every about 2 hours on average. If travelling with Trenitalia, you need to know the Pisa to Milazzo train schedule: the first train leaves at 00:01, while the last ride is at 19:13. A Pisa to Milazzo train cost about 58.0 €. But how long is the train ride from Pisa to Milazzo? Your journey takes about 13 hours on average. Trenitalia offers 1 direct trains between these two cities.