Pisa to Syracuse trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Pisa Centrale and arrive at Siracusa every about 2 hours on average. If travelling with Trenitalia, you need to know the Pisa to Syracuse train schedule: the first train leaves at 00:01, while the last ride is at 19:13. A Pisa to Syracuse train cost about 121.80 €. But how long is the train ride from Pisa to Syracuse? Your journey takes about 15 hours on average. Trenitalia offers 1 direct trains between these two cities. Thanks to Trenitalia, offers, you can save on your trip from Pisa to Syracuse and find low cost tickets starting from 64 €!