Pistoia to Messina trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Pistoia and arrive at Messina Centrale every about 2 hours on average. If travelling with Trenitalia, you need to know the Pistoia to Messina train schedule: the first train leaves at 09:12, while the last ride is at 21:44. A Pistoia to Messina train cost about 92.3 €. But how long is the train ride from Pistoia to Messina? Your journey takes about 11 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Pistoia to Messina and find low cost tickets starting from 33 €!