Pontedera to Messina trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Pontedera-Casciana Terme and arrive at Messina Centrale every about 2 hours on average. If travelling with Trenitalia, you need to know the Pontedera to Messina train schedule: the first train leaves at 01:36, while the last ride is at 22:55. A Pontedera to Messina train cost about 71.5 €. But how long is the train ride from Pontedera to Messina? Your journey takes about 12 hours on average.