Prato to Niscemi trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Prato Porta al Serraglio and arrive at Niscemi every about 6 hours on average. If travelling with Trenitalia, you need to know the Prato to Niscemi train schedule: the first train leaves at 19:39, while the last ride is at 20:34. A Prato to Niscemi train cost about 85.0 €. But how long is the train ride from Prato to Niscemi? Your journey takes about 11 hours on average.