Ragusa to Brindisi trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Ragusa and arrive at Brindisi every about 12 hours on average. If travelling with Trenitalia, you need to know the Ragusa to Brindisi train schedule: the first train leaves at 19:04, while the last ride is at 19:04. A Ragusa to Brindisi train cost about 133.85 €. But how long is the train ride from Ragusa to Brindisi? Your journey takes about 21 hours on average.