Rome to Alessandria trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Roma Termini and arrive at Alessandria every 60 minutes on average. If travelling with Trenitalia, you need to know the Rome to Alessandria train schedule: the first train leaves at 06:00, while the last ride is at 22:35. A Rome to Alessandria train cost about 67.0 €. But how long is the train ride from Rome to Alessandria? Your journey takes about 6 hours on average. Trenitalia offers 1 direct trains between these two cities. Thanks to Trenitalia, offers, you can save on your trip from Rome to Alessandria and find low cost tickets starting from 19 €! If you need to travel this week, prices range from 54.90 € to 54.90€.