Rome to Caltanissetta trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Roma Termini and arrive at Caltanissetta Centrale every about 4 hours on average. If travelling with Trenitalia, you need to know the Rome to Caltanissetta train schedule: the first train leaves at 21:31, while the last ride is at 22:26. A Rome to Caltanissetta train cost about 97.1 €. But how long is the train ride from Rome to Caltanissetta? Your journey takes about 13 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Rome to Caltanissetta and find low cost tickets starting from 67 €!