Rome to Marsala trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Roma Termini and arrive at Mozia-Birgi every about 4 hours on average. If travelling with Trenitalia, you need to know the Rome to Marsala train schedule: the first train leaves at 21:31, while the last ride is at 22:26. A Rome to Marsala train cost about 107.25 €. But how long is the train ride from Rome to Marsala? Your journey takes about 17 hours on average.