Rome to Marsala trains might be a good value for money solution; travelling in Italy by train is often rather cheap and faster than taking a bus indeed. You can count on 3 daily rides to get from Rome to Marsala. The first train to Marsala leaves from Rome at 21:31 and the last train departs at 22:26. If you choose a local train the trip lasts on average 16:01 hours. For your trip from Rome to Marsala by train you can choose to leave from one of Rome main stations: Roma Termini On Wanderio you can compare all schedules, fares and railway companies to Marsala and book the best itinerary starting from Rome.