Rome to Mazara del Vallo trains might be a good value for money solution; travelling in Italy by train is often rather cheap and faster than taking a bus indeed. You can count on 4 daily rides to get from Rome to Mazara del Vallo. Trains leave from Roma Termini and arrive at Mazara del Vallo every about 3 hours on average. The trip by train from Rome to Mazara del Vallo last on average 15:30 travelling with high-speed trains (Frecciarossa or Italotreno) If travelling with Trenitalia, you need to know the Rome to Mazara del Vallo train schedule: the first train leaves at 21:31, while the last ride is at 22:26. A Rome to Mazara del Vallo train cost about 67.5 €. But how long is the train ride from Rome to Mazara del Vallo? Your journey takes about 17 hours on average. Thanks to Trenitalia offers, you can save on your trip from Rome to Mazara del Vallo and find prices starting from 69 €!