Rome to Messina trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Roma Termini and arrive at Messina Centrale every about 4 hours on average. If travelling with Trenitalia, you need to know the Rome to Messina train schedule: the first train leaves at 21:31, while the last ride is at 22:26. A Rome to Messina train cost about 39.90 €. But how long is the train ride from Rome to Messina? Your journey takes about 8 hours on average. Trenitalia offers 2 direct trains between these two cities. Thanks to Trenitalia, offers, you can save on your trip from Rome to Messina and find low cost tickets starting from 19 €! If you need to travel this week, prices range from 44.90 € to 44.90€. Booking your train ticket a few weeks in advance though, you can find low cost trains from Rome to Messina with fares starting from 39.90€, saving 54% on average.