Rome to Niscemi trains might be a good value for money solution; travelling in Italy by train is often rather cheap and faster than taking a bus indeed. You can count on 4 daily rides to get from Rome to Niscemi. Trains leave from Roma Termini and arrive at Niscemi every about 3 hours on average. The trip by train from Rome to Niscemi last on average 12:40 travelling with high-speed trains (Frecciarossa or Italotreno) If travelling with Trenitalia, you need to know the Rome to Niscemi train schedule: the first train leaves at 07:35, while the last ride is at 22:26. A Rome to Niscemi train cost about 92.65 €. But how long is the train ride from Rome to Niscemi? Your journey takes about 15 hours on average.